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Detroit Lions Defeat Arizona Cardinals 45-21 in Week 5 NFL Action

The Detroit Lions secured a decisive 45-21 victory over the Arizona Cardinals during their Week 5 matchup.

2 publishers · 20 articles · first seen 8 Oct 2026 · updated 26d ago

Headline and summary written by an AI model from the linked articles; not reviewed by a person. How this was made

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The odds

How the odds moved · Will the Arizona Cardinals win the 2027 NFL league championship?
0%50%100%0%12 Sept, 18:39 UTCnowSI Feed: Detroit Lions Snap Counts Against Cardinals Reveals DB Lost Job Again · 12 Oct, 13:32 UTCSI Feed: Detroit Lions Grades: Offense Shakes Off Struggles, Mows Down Cardinals · 12 Oct, 12:00 UTCSI Feed: 8 Winners, 3 Losers From Lions’ Win Over Cardinals · 12 Oct, 01:30 UTCSI Feed: 4 Big Instant Reactions After Cardinals' Humiliating Loss to Lions · 12 Oct, 00:45 UTCSI Feed: Key Takeaways From Detroit Lions 45-21 Victory Over Arizona Cardinals · 11 Oct, 23:28 UTCSI Feed: Roundtable: Previewing Lions Week 5 Matchup Against Cardinals · 11 Oct, 20:15 UTCCBS Sports Headlines: Lions vs. Cardinals odds, picks, NFL Week 5 prediction, spread, line: start time, betting preview, best bets · 11 Oct, 18:45 UTCSI Feed: Cardinals vs. Lions: 3 Expert Bets to Target in Your Week 5 Parlay · 11 Oct, 16:46 UTCSI Feed: Lions Insider Answers 5 Biggest Questions Ahead of Cardinals Week 5 Clash · 11 Oct, 15:15 UTCSI Feed: Detroit Lions Week 5 Updated Depth Chart Against Cardinals · 11 Oct, 12:16 UTCSI Feed: Expert Predictions For Detroit Lions Matchup With Arizona Cardinals · 11 Oct, 11:03 UTCCBS Sports Headlines: Lions vs. Cardinals odds, picks, prediction, spread, line: NFL Week 5 start time, betting preview, best bets · 11 Oct, 09:00 UTCSI Feed: 3 Lions Players Who Need to Bounce Back Against Cardinals · 10 Oct, 22:45 UTCSI Feed: How To Watch, Listen, Stream Detroit Lions Against Arizona Cardinals · 10 Oct, 18:55 UTCSI Feed: Spot the Ball: 10 Thoughts Ahead of Lions Matchup Against Cardinals · 9 Oct, 23:00 UTCSI Feed: Walter Nolen Headlines Final Cardinals-Lions Week 5 Injury Report · 9 Oct, 20:53 UTCSI Feed: Detroit Lions Rule Out Four Against Cardinals, DT Questionable · 9 Oct, 19:55 UTCSI Feed: Cardinals vs Lions Week 5 Expert Picks, Prediction Roundup · 9 Oct, 16:57 UTCSI Feed: Cardinals Add Star Defender to Week 5 Injury Report vs Lions · 8 Oct, 23:09 UTCSI Feed: Cardinals-Lions Official Week 5 Injury Report · 8 Oct, 00:57 UTC

Each tick is a source publishing on this story

Price data
TimeChance of yes
now0%
12 Sept, 18:39 UTC1%

The story so far

2 publishers have covered this in 20 articles since 8 Oct 2026. SI Feed published first, on 8 October at 00:57 UTC; CBS Sports Headlines followed 80h 03m later. The most recent article, from SI Feed, appeared on 12 October at 13:32 UTC.

Outlets reporting it: SI Feed, CBS Sports Headlines.

One prediction market prices this story:

  • Will the Arizona Cardinals win the 2027 NFL league championship? — the market puts it at 0%, with $5k traded in the last 24 hours, closing 1 Apr 2027. The Yes outcome occurs if the Arizona Cardinals win the 2027 NFL league championship. The No outcome applies if any other team wins or if the Cardinals are eliminated from contention before the title game is played. Readers often mistake the linked Week 4 power rankings for the final result, but only the actual championship winner matters.

Odds are the market's probability that the outcome happens, updated every few minutes. They are information about what traders expect, not a forecast we make and not investment advice.

How it unfolded

Every source in the order it published, with the odds on Will the Arizona Cardinals win the 2027 NFL league championship? at that moment. A dash means the source published before we started tracking prices.

  1. SI FeedCardinals-Lions Official Week 5 Injury Report1%
  2. SI FeedCardinals Add Star Defender to Week 5 Injury Report vs Lions1%
  3. SI FeedCardinals vs Lions Week 5 Expert Picks, Prediction Roundup1%
  4. SI FeedDetroit Lions Rule Out Four Against Cardinals, DT Questionable1%
  5. SI FeedWalter Nolen Headlines Final Cardinals-Lions Week 5 Injury Report1%
  6. SI FeedSpot the Ball: 10 Thoughts Ahead of Lions Matchup Against Cardinals1%
  7. SI FeedHow To Watch, Listen, Stream Detroit Lions Against Arizona Cardinals1%
  8. SI Feed3 Lions Players Who Need to Bounce Back Against Cardinals1%
  9. CBS Sports HeadlinesLions vs. Cardinals odds, picks, prediction, spread, line: NFL Week 5 start time, betting preview, best bets1%
  10. SI FeedExpert Predictions For Detroit Lions Matchup With Arizona Cardinals1%
  11. Show 10 later sources
    1. SI FeedDetroit Lions Week 5 Updated Depth Chart Against Cardinals1%
    2. SI FeedLions Insider Answers 5 Biggest Questions Ahead of Cardinals Week 5 Clash1%
    3. SI FeedCardinals vs. Lions: 3 Expert Bets to Target in Your Week 5 Parlay1%
    4. CBS Sports HeadlinesLions vs. Cardinals odds, picks, NFL Week 5 prediction, spread, line: start time, betting preview, best bets1%
    5. SI FeedRoundtable: Previewing Lions Week 5 Matchup Against Cardinals1%
    6. SI FeedKey Takeaways From Detroit Lions 45-21 Victory Over Arizona Cardinals1%
    7. SI Feed4 Big Instant Reactions After Cardinals' Humiliating Loss to Lions1%
    8. SI Feed8 Winners, 3 Losers From Lions’ Win Over Cardinals1%
    9. SI FeedDetroit Lions Grades: Offense Shakes Off Struggles, Mows Down Cardinals1%
    10. SI FeedDetroit Lions Snap Counts Against Cardinals Reveals DB Lost Job Again1%
  12. Current odds0%

Sources

Every article we clustered into this story. Headlines link to the publisher.

  1. Detroit Lions Snap Counts Against Cardinals Reveals DB Lost Job Again SI Feed
  2. Detroit Lions Grades: Offense Shakes Off Struggles, Mows Down Cardinals SI Feed
  3. 8 Winners, 3 Losers From Lions’ Win Over Cardinals SI Feed
  4. 4 Big Instant Reactions After Cardinals' Humiliating Loss to Lions SI Feed
  5. Key Takeaways From Detroit Lions 45-21 Victory Over Arizona Cardinals SI Feed
  6. Roundtable: Previewing Lions Week 5 Matchup Against Cardinals SI Feed
Show 14 more sources
  1. Lions vs. Cardinals odds, picks, NFL Week 5 prediction, spread, line: start time, betting preview, best bets CBS Sports Headlines
  2. Cardinals vs. Lions: 3 Expert Bets to Target in Your Week 5 Parlay SI Feed
  3. Lions Insider Answers 5 Biggest Questions Ahead of Cardinals Week 5 Clash SI Feed
  4. Detroit Lions Week 5 Updated Depth Chart Against Cardinals SI Feed
  5. Expert Predictions For Detroit Lions Matchup With Arizona Cardinals SI Feed
  6. Lions vs. Cardinals odds, picks, prediction, spread, line: NFL Week 5 start time, betting preview, best bets CBS Sports Headlines
  7. 3 Lions Players Who Need to Bounce Back Against Cardinals SI Feed
  8. How To Watch, Listen, Stream Detroit Lions Against Arizona Cardinals SI Feed
  9. Spot the Ball: 10 Thoughts Ahead of Lions Matchup Against Cardinals SI Feed
  10. Walter Nolen Headlines Final Cardinals-Lions Week 5 Injury Report SI Feed
  11. Detroit Lions Rule Out Four Against Cardinals, DT Questionable SI Feed
  12. Cardinals vs Lions Week 5 Expert Picks, Prediction Roundup SI Feed
  13. Cardinals Add Star Defender to Week 5 Injury Report vs Lions SI Feed
  14. Cardinals-Lions Official Week 5 Injury Report SI Feed

Related prediction markets

Linked by software because they are about the same subject. Most ask a different question from the one this story reports, so read each market's own question. How often the link is right

  • Polymarket Will the Arizona Cardinals win the 2027 NFL league championship? 0% $5k 24hends 1 Apr 2027

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In this story

  • Detroit Lions
  • Arizona Cardinals
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